Saphris: A Comprehensive Medication Guide Saphris, also known as asenapine, is a medication prescribed primarily for the treatment of psychotic disorders such as schizophrenia and bipolar disorder. It is an antipsychotic medication that works by regulating the levels of certain neurotransmitters like dopamine and serotonin in the brain. This article will provide a comprehensive guide to Saphris, covering its uses, dosage, demographics, side effects, interactions, and generic options. Uses of Saphris Saphris is primarily prescribed for the treatment of psychotic disorders such as schizophrenia and bipolar disorder. It is also used in the treatment of depression, anxiety, and post-traumatic stress disorder (PTSD) as an adjunct medication. Saphris can be used to treat acute manic or mixed episodes associated with bipolar disorder, and it can also be used for long-term maintenance therapy. Dosage of Saphris Saphris is available in sublingual tablet form and is taken once or twice daily, depending on the individual’s condition. The recommended starting dose for adults is 5 mg sublingually twice daily. If necessary, the dose can be increased by 5 mg per day (up to a maximum dose of 10 mg twice daily). The maximum dose in elderly patients is 5 mg twice daily. Saphris should be taken at the same time each day with or without food. Demographics of Saphris Saphris is approved for use in adults over 18 years of age. It is not approved for use in children or adolescents under 18 years of age. Saphris is also not recommended for use in elderly patients with dementia-related psychosis due to an increased risk of death. Side Effects of Saphris Like all medications, Saphris can cause side effects. Some common side effects of Saphris include sedation, dizziness, and akathisia (restlessness). Other side effects that may occur include weight gain, extrapyramidal symptoms, and increased appetite. Rare but serious side effects include allergic reactions, pancreatitis, and agranulocytosis (a significant reduction in white blood cell count). In rare cases, Saphris can cause Neuroleptic Malignant Syndrome (NMS), a potentially deadly condition characterized by high fever, muscle rigidity, altered mental status, and autonomic dysfunction. Interactions of Saphris Saphris can interact with other medications, including antihistamines, benzodiazepines, and other antipsychotic medications. Patients taking Saphris should inform their doctor of all medications they are taking, including over-the-counter drugs and supplements. Saphris should not be taken with alcohol or other CNS depressants, as this can increase the risk of respiratory depression and may lead to death. Saphris has sedative effects, and patients are advised not to drive or operate heavy machinery until they know how the medication affects them. Generic Options of Saphris Saphris is a brand name medication and does not have a generic equivalent. The patent for Saphris expired in 2017, and the medication is now available as a generic drug called Asenapine. Generic options of Saphris may be more affordable but have the same efficacy and safety profile as the brand name medication. Conclusion Saphris is a medication prescribed for the treatment of psychotic disorders such as schizophrenia and bipolar disorder. It is an antipsychotic medication that works by regulating the levels of certain neurotransmitters in the brain. The medication is available in sublingual tablet form and is taken once or twice daily, depending on the individual’s condition. Saphris has both common and rare side effects and can interact with other medications. Patients taking Saphris should inform their doctor of all medications they are taking. Saphris is a brand name medication and does not have a generic equivalent. The patent for Saphris expired in 2017, and the medication is now available as a generic drug called Asenapine. Patients should always consult their healthcare provider before starting or stopping medication.