Samsca: A Potent Diuretic for Treating Severe Hyponatremia Samsca is the brand name for the drug Tolvaptan, an aquaretic diuretic used to treat severe hyponatremia in adults. Hyponatremia is a condition where the concentration of sodium in the blood is low, usually below 135 mEq/L. Samsca increases the excretion of water while preserving sodium levels and is approved to treat euvolemic and hypervolemic hyponatremia. This article covers the uses, dosage, demographic, side effects, interactions, and generic options for Samsca. Uses Samsca is indicated for severe hyponatremia in adults, which can be caused by a variety of conditions, including heart failure, liver disease, and the syndrome of inappropriate antidiuretic hormone secretion (SIADH). Hyponatremia can lead to seizures, coma, and death if left untreated. Samsca treats hyponatremia by increasing the excretion of water, which dilutes the blood and raises sodium levels. Dosage The recommended starting dose of Samsca is 15 mg once daily for up to 30 days. The dose can be increased to 30 mg once daily after the first 24 hours if necessary. The maximum dose of Samsca is 60 mg once daily. Samsca should be taken with food and should not be crushed, chewed or dissolved. Patients with moderate to severe renal impairment should be monitored closely while taking Samsca. Demographic Samsca is approved for use in adults only and is not recommended for pediatric use. Samsca is available by prescription only and can be obtained from licensed healthcare providers. It is important to follow the dosage options provided by your doctor, and not to change dosage without consulting them first. Side Effects Like all medications, Samsca may cause side effects in some patients. The most common side effects of Samsca include thirst, dry mouth, nausea, and dizziness. Serious side effects include rapid weight gain, difficulty urinating, and signs of liver damage such as dark urine or yellowing of the skin and eyes. Interactions Samsca should not be used in combination with strong CYP3A4 inhibitors such as ketoconazole and clarithromycin. Samsca may also interact with other medications, including digoxin, cyclosporine, and rifampin, and patients should inform their doctor of any drugs they are taking before starting Samsca. Generic Options Tolvaptan is available as a generic drug and is FDA approved. The generic version is available at a lower cost than Samsca and may be a more affordable option for some patients. Conclusion Samsca is a potent diuretic that is used to treat severe hyponatremia in adults. It works by increasing the excretion of water while preserving sodium levels. Samsca is available only by prescription and should only be taken under the supervision of a licensed healthcare provider. Like all medications, Samsca may cause side effects and may interact with other medications. Patients should consult their doctor before starting Samsca. The generic version of Samsca may be a more affordable option for some patients.