Renagel: Uses, Dosage, Demographic, Side Effects, Interactions, and Generic Options Renagel is a prescription medication used to control phosphorus levels in people with chronic kidney disease. It is known generically as sevelamer hydrochloride. The drug blocks the absorption of phosphorus from food in the digestive tract, and it helps to maintain normal levels of the mineral in the blood. This article provides information on the uses, dosage recommendations, demographics affected, side effects, drug interactions, and generic options for Renagel. Uses of Renagel Chronic kidney disease (CKD) causes a build-up of phosphorus in the blood, which can lead to a range of health problems, including bone disease and heart disease. Patients with CKD require regular dialysis or kidney transplants to remove excess phosphorus from their blood. Renagel is used to control phosphorus levels in patients on dialysis or who have unsatisfactory levels of phosphorus. Dosage Recommendations for Renagel The dosage of Renagel recommended by physicians varies depending on a patient's age and weight. The dose is usually increased gradually, with the maximum dose of Renagel being four tablets taken orally three times a day, with meals. The tablets should be swallowed whole, without crushing or chewing. Dosage adjustments may be necessary if a patient's serum phosphorus levels fall below the recommended levels. Demographics Affected by Renagel Renagel is frequently prescribed to people with end-stage renal disease (ESRD), a condition where the kidneys fail completely. According to the National Kidney Foundation, there are over 750,000 people in the United States living with ESRD. Renagel may also be prescribed to people with earlier stages of chronic kidney disease. Side Effects of Renagel Some of the common side effects of Renagel include nausea, vomiting, diarrhea, indigestion, constipation, and abdominal pain. These side effects may be more likely to occur in people with pre-existing digestive disorders. Renagel can also bind with other medications in the digestive tract, reducing their effectiveness. Additionally, the drug can interfere with the absorption of fat-soluble vitamins, which can lead to vitamin deficiencies over time. Interactions with Other Medications Renagel can interact with a range of medications, including propranolol, ciprofloxacin, and levothyroxine. Patients should inform their healthcare providers about all the medications they are taking before starting Renagel. Adjustments to the dose of other medications may be necessary to ensure they are properly absorbed. Generic Options for Renagel Sevelamer carbonate is the generic version of Renagel. It has the same formulation as Renagel but is modified to be more soluble in water, reducing the number of tablets required to achieve the same dose. Sevelamer carbonate is more expensive than Renagel, but it may be preferred for patients who have difficulty swallowing tablets or who experience gastrointestinal issues when taking Renagel. In conclusion, Renagel is a medication used to control phosphorus levels in people with chronic kidney disease. It is prescribed to people undergoing dialysis or who have difficulty regulating their serum phosphorus levels. The recommended dosage of Renagel varies depending on a patient's weight and age, and dosage adjustments may be necessary over time. Renagel can cause side effects such as nausea, vomiting, and abdominal pain, and it can interact with other medications. Generic options for Renagel are available in the form of sevelamer carbonate, which may be preferred for certain patients. Patients should consult with their healthcare provider to determine the appropriate dosage and treatment plan for their individual needs.