Relistor: A Detailed Guide on Uses, Dosage, Demographic, Side Effects, Interactions, and Generic Options Introduction Relistor is a medication that is used to treat constipation caused by opioid medications in individuals with chronic non-cancer pain. This medication is useful in individuals who have failed traditional laxatives. Relistor is commonly used in hospitalized patients who require opioid treatment and is also prescribed for cancer patients. Uses of Relistor Relistor is a medication that works by blocking the actions of opioids on the gastrointestinal tract, thus relieving constipation. It is used to treat chronic constipation caused by opioid medications in individuals with chronic non-cancer pain. It is also used in individuals with advanced illness who are receiving palliative care to relieve constipation caused by opioid treatments. Dosage of Relistor Relistor is available in two dosage strengths of 8 mg and 12 mg. The recommended dosage for patients with chronic non-cancer pain is 8 mg injected subcutaneously every other day. For patients with advanced illness receiving palliative care, the recommended dosage is 8 mg. If there is no response after the first dose, a second dose of 8 mg may be administered within 24 hours. Demographic of Relistor Relistor is indicated for use in adults. The medication should not be used in children or adolescents under the age of 18. Side Effects of Relistor The most common side effects associated with Relistor are nausea, diarrhea, abdominal pain, and flatulence. Other side effects include headache, dizziness, sweating, hot flushes, and vomiting. Some individuals may experience severe side effects like allergic reactions, which may cause hives, difficulty breathing, and swelling in the face, tongue, throat, or lips. Interactions of Relistor Relistor may interact with other medications, including opioid analgesics, which may also cause constipation. Therefore, clinicians should be aware of the potential for these interactions and should monitor patients for adverse effects. The use of Relistor with other medications that cause constipation, such as anticholinergic agents, may reduce the effectiveness of treatment. Generic Options of Relistor Relistor is available as a brand name medication only, and there are currently no generic versions available. However, there are other medications that work similarly to Relistor, such as Lubiprostone (Amitiza) and Linaclotide (Linzess), which are indicated for the treatment of chronic idiopathic constipation. Conclusion Relistor is an effective medication for treating chronic non-cancer pain and advanced illness patients who are experiencing constipation. It works by blocking the actions of opioids in the gastrointestinal tract, thus relieving constipation. The medication has some potential side effects, and clinicians should be aware of possible interactions with other medications that may also cause constipation. While there are currently no generic versions of Relistor available, other medications are available that may provide similar benefits.