Rapamune: A Medication Guide Introduction: Rapamune (sirolimus) is a prescription medication known as an immunosuppressant. It is used primarily to prevent organ rejection among patients who have undergone kidney transplantation. The medication works by suppressing the action of the immune system, which helps prevent the body from rejecting the transplanted organ or tissue. Rapamune belongs to a class of drugs called mTOR inhibitors. Uses: Rapamune is used to prevent organ rejection in patients who have undergone kidney transplantation. It is typically prescribed in combination with other immunosuppressive medications, such as cyclosporine and corticosteroids. In addition to kidney transplantation, doctors may also prescribe Rapamune for the prevention of organ rejection in liver transplantation, heart transplantation, and lung transplantation. Dosage: Rapamune is available in the form of tablets for oral use. The medication should be taken once daily, at the same time every day. The recommended starting dosage of Rapamune is 6 mg, given once a day. The dosage may be increased or decreased based on individual patient needs. The maximum recommended daily dose of Rapamune is 40mg. Demographic: Rapamune is typically prescribed to adults who have undergone organ transplantation. The medication is not recommended for use in children and adolescents. Side Effects: Like all medications, Rapamune can cause side effects. Some common side effects include: 1. Infections such as colds, flu, and other viral and bacterial infections 2. Diarrhea, nausea, and vomiting 3. Headache, dizziness, and fatigue 4. High blood sugar levels 5. Difficulty sleeping and depression 6. Skin rash and itching 7. Mouth sores and ulcers More severe side effects may include: 1. High blood pressure 2. Increased cholesterol levels 3. Kidney problems and reduced kidney function 4. Decreased platelet count 5. Increased risk of certain cancers, such as skin and lymphoma Interactions: Rapamune may interact with other medications. It should not be used in combination with cyclosporine, unless under the supervision of a doctor. Other medications that may interact with Rapamune include: 1. Antibiotics such as clarithromycin and erythromycin 2. Antifungal medications such as fluconazole and itraconazole 3. Medications used to treat tuberculosis such as rifabutin and rifampin 4. Certain antidepressant and antipsychotic medications It is important to talk to your doctor about all medications you are currently taking before starting treatment with Rapamune. Generic Options: Sirolimus is the generic name for Rapamune, and several generic versions of the medication are available. These generics are often less expensive than the brand name product but are just as effective in preventing organ rejection. Conclusion: Rapamune is an important medication used to prevent organ rejection among patients who have undergone kidney transplantation. While the medication is generally safe and effective, it can cause side effects in some patients. As with all medications, it is important to talk to your doctor about any concerns or questions you may have about Rapamune. Be sure to report any side effects or interactions to your doctor immediately.