Neupogen: Uses, Dosage, Demographic, Side Effects, Interactions and Generic Options Neupogen (filgrastim) is a synthetic protein that stimulates the formation of white blood cells. It is used to treat neutropenia (a deficiency of white blood cells caused by chemotherapy) and other conditions that lead to an increased risk of infections. Uses Neupogen is used to reduce the chance of infection in individuals who have undergone chemotherapy. Chemotherapy damages not only cancer cells, but also healthy cells including white blood cells that fight infections. This makes the person more vulnerable to infections. Neupogen increases the number of white blood cells that help fight infections and reduces the duration of neutropenia. In addition to its use in cancer patients, Neupogen is also used in patients undergoing bone marrow transplantation. It helps to increase the production of white blood cells needed after a bone marrow transplant. Neupogen can also be used to reduce the chance of infection in patients with HIV who are taking certain medications that may lower their white blood cell count. Dosage Neupogen is available in two forms; an injection that is given under the skin (subcutaneous) and one administered through a vein (intravenous). The correct dosage will depend on the condition, weight, and age of the patient. Dosage is usually based on how low the white blood cell count is and how long it has been low. Neupogen is usually given once a day for up to two weeks. It is important to follow the instructions given by your healthcare provider for proper administration of this medication. Demographic Neupogen is indicated for use in adults and children who are at least a month old. It is also safe for use in pregnant or breastfeeding women. However, the benefits and risks should be weighed before use in these populations. Side Effects Like all medications, Neupogen can cause side effects. The most common side effects include bone pain, muscle aches, headaches, and injection site reactions. Other less common side effects include fever, rash, respiratory symptoms like cough and difficulty breathing, and swelling of the face, tongue, or throat. In severe cases, Neupogen can cause an allergic reaction, which can be life-threatening. Interactions Neupogen should not be taken with chemotherapy drugs or radiation therapy without consultation from your healthcare provider. These treatments may further lower white blood cell counts and increase the risk of infections. Drugs that stimulate the immune system such as interleukins may increase the risk of side effects when taken with Neupogen. It is important to inform your healthcare provider of any medications you are taking before starting Neupogen. Generic Options In the United States, Neupogen is the brand name of filgrastim manufactured by Amgen. There are currently no FDA approved generic alternatives for Neupogen. Conclusion Neupogen is a medication used to reduce the chance of infection in people receiving chemotherapy, undergoing bone marrow transplant, or those with neutropenia. It is important to follow the instructions of your healthcare provider and report any side effects immediately. Although there are no generic alternatives to Neupogen, it is possible to ask your healthcare provider about similar medications to treat your condition.