Movantik: A Comprehensive Guide on Uses, Dosage, Demographic, Side Effects, Interactions, and Generic Options If you suffer from chronic constipation, you know how frustrating it can be. Movantik might be able to offer you some relief. Movantik is a prescription medication used to treat opioid-induced constipation in adults with non-cancer pain. This article provides a comprehensive guide on Movantik covering uses, dosage, demographic, side effects, interactions, and generic options. What is Movantik? Movantik is a medication that contains naloxegol, a peripherally acting mu-opioid receptor antagonist (PAMORA), which works by blocking opioids in the gut, helping to relieve constipation. It was approved by the FDA in 2014 for the treatment of opioid-induced constipation in adults with non-cancer pain. Uses Movantik is prescribed to relieve constipation caused by opioids. Opioids are commonly prescribed for pain management, but they can also cause constipation, a common and debilitating side effect. In clinical trials, Movantik has been shown to be safe and effective for the treatment of opioid-induced constipation. Dosage Movantik comes in the form of a tablet, and it is taken once per day on an empty stomach, at least 1 hour before or 2 hours after eating. The recommended dose of Movantik is 25 mg once daily. If the patient experiences intolerable side effects, the dose may be reduced to 12.5 mg once daily. Demographic Movantik is indicated for use in adults with chronic non-cancer pain who have been taking opioids and who have constipation that does not respond to other treatments. Movantik is not recommended for use in patients with cancer pain or those receiving palliative care. Side Effects Movantik may cause side effects, as with any medication. The most common side effects reported include abdominal pain, diarrhea, nausea, vomiting, and headache. If you experience severe or persistent side effects, be sure to contact your healthcare provider. Interactions Movantik can interact with other medications, leading to serious side effects. Patients should inform their healthcare provider if they are taking any of the following medications before starting Movantik: - strong CYP3A4 inhibitors (such as ketoconazole, itraconazole, and ritonavir) - moderate CYP3A4 inhibitors (such as diltiazem, verapamil, and erythromycin) - strong CYP3A4 inducers (such as rifampin and carbamazepine) - P-gp inhibitors (such as cyclosporine, quinidine, and verapamil) Generic Options The generic version of Movantik, naloxegol, is not yet available in the United States but is available in other countries. However, it is important to note that not all medications are interchangeable with their generic counterparts, and patients should speak with their healthcare provider before making any changes. Conclusion Movantik is a safe and effective medication that can offer relief for those with opioid-induced constipation. It is important to follow the dosage prescribed by your healthcare provider and inform them of any other medications you are taking. While Movantik is not yet available in generic form in the United States, it may be available elsewhere. If you have any questions or concerns about using Movantik, be sure to speak with your healthcare provider.