Metastron (Strontium-89) – Uses, Dosage, Demographic, Side Effects, Interactions, and Generic Options As a therapeutic radiopharmaceutical, Metastron has become an important treatment option for patients suffering from painful bone metastases caused by cancers such as prostate, breast, and lung cancer. This article will explore the uses, dosage, demographic, side effects, interactions, and generic options of Metastron. Uses of Metastron: The primary use of Metastron is to treat bone pain that occurs due to the spread of cancer cells to the bones, which is known as bone metastasis. The treatment is particularly effective for patients with prostate, breast, or lung cancer. It involves the administration of Strontium-89 into the bloodstream, which accumulates in bones and delivers high-energy radiation to the affected areas. The radiation works by killing the cancer cells, reducing pain and other symptoms and improving the quality of life for patients. Dosage: Metastron is administered as an injection into the vein, and the dosage depends on the patient’s body surface area. The recommended dose is 1.44 MBq per kg of body weight. The maximum dose that can be administered in a single injection is 150 MBq. The dose should be adjusted based on the patient’s renal function. Demographic: Metastron is used to treat bone pain in patients with predominant bone metastasis from solid tumors like prostate, breast, and lung cancer. It is most commonly used in patients who have failed to respond to or cannot tolerate conventional therapy like chemotherapy or radiation therapy. Side Effects: Metastron causes some side effects in patients, which are primarily related to the radiation delivered to the tumors. These side effects are usually mild and temporary, and they include fatigue, nausea, vomiting, bone pain, and low blood cell count. The risk of side effects can be reduced by following proper safety measures and monitoring the patient’s medical condition carefully. Interactions: Metastron should not be administered together with other radioactive drugs or substances, as this could increase the risk of radiation toxicity. Patients should inform their healthcare provider about any medications they are taking, including prescription or non-prescription drugs, dietary supplements, and herbal remedies. Generic Options: Metastron is a brand-name drug that is patented by GE Healthcare. However, there are several generic alternatives available, including Strontium-89 Chloride and Metastron® – Strontium-89. These alternatives offer the same therapeutic benefits as the brand-name drug at a lower cost. Conclusion: In conclusion, Metastron is an effective treatment option for patients suffering from bone pain due to cancer metastasis. It delivers high-energy radiation to the affected areas of the bones, killing cancer cells and reducing pain. The dosage for Metastron is based on the patient’s body surface area, and the drug has mild and temporary side effects. Metastron should not be administered together with other radioactive drugs or substances, and there are several generic alternatives available at a lower cost. Patients should consult their healthcare provider to determine if Metastron is right for them.