Makena, also known as hydroxyprogesterone caproate, is a hormone medication that is used to reduce the risk of preterm birth in pregnant women who have had a prior preterm birth. It is typically administered as an injection and is used during the second and third trimesters of pregnancy. In this article, we will cover the uses, dosage, demographic, side effects, interactions, and generic options of Makena. Uses of Makena Makena is primarily used to reduce the risk of preterm birth in women who have a high risk of delivering their baby early. Preterm birth is defined as giving birth before 37 weeks of pregnancy. Makena is commonly prescribed to women who have had a prior preterm birth. The medication helps to reduce the risk of preterm birth by decreasing contractions in the uterus and maintaining the thickness of the cervical mucus plug. Dosage of Makena The recommended dose of Makena is 250 mg given as an injection into the muscle of the hip once a week starting at 16 to 20 weeks of pregnancy and continued until week 37 or until delivery. The medication should only be administered by a healthcare provider who is trained in giving injections. Demographic of Makena Makena is typically prescribed to pregnant women who have a history of preterm birth. Women who have completed their 16th to 20th week of pregnancy and have a cervix length shorter than 25 mm are also eligible to receive Makena injections. Side Effects of Makena Like all medications, Makena may cause side effects. The most common side effects of Makena are pain and swelling at the injection site. Some women may also experience hives, itching, or difficulty breathing. If you experience any of these symptoms, seek medical attention immediately. Interactions of Makena It is important to inform your healthcare provider of all medications you are currently taking before receiving Makena injections. Makena may interact with certain medications, including progesterone-containing products and medications used to treat blood clots. Generic Options of Makena A generic version of Makena is available under the name hydroxyprogesterone caproate. This generic medication has been approved by the FDA and is available at a lower cost than the brand-name version. In conclusion, Makena is a medication that is used to reduce the risk of preterm birth in pregnant women who have had a prior preterm birth. It is administered as an injection and helps to decrease contractions in the uterus and maintain the thickness of the cervical mucus plug. The recommended dose of Makena is 250 mg once a week starting at 16 to 20 weeks of pregnancy. Common side effects of Makena include pain and swelling at the injection site. Makena may interact with certain medications and a generic version of the medication is available. If you have a history of preterm birth or have a cervix length shorter than 25 mm, talk to your healthcare provider to see if Makena is right for you.