Korlym: Medical Uses, Dosage, and Side Effects Korlym is a medication that is primarily used to manage the side effects of hypercortisolism in adults who have severe endogenous Cushing's syndrome. The active ingredient in Korlym is mifepristone, which works by binding to gluco- and mineralocorticoid receptors in the brain, thereby blocking the effects of cortisol on these receptors. Uses Cushing's syndrome is a rare medical condition that is characterized by the excessive production of cortisol in the body. This can cause a wide range of symptoms, including weight gain, high blood pressure, diabetes, and increased susceptibility to infections. Korlym is used to manage the symptoms of Cushing's syndrome in adults who have not responded well to other treatments. Dosage The recommended starting dose of Korlym is 300 mg per day, taken orally with food. The dose can be increased to 1200 mg per day if needed, although most patients are able to manage their symptoms with a lower dose. It is important to take Korlym exactly as prescribed by your healthcare provider and to avoid missing any doses. Demographic Korlym is approved for use in adults who have severe endogenous Cushing's syndrome and have not responded well to other treatments. It is not appropriate for use in children or adolescents, and it should not be used during pregnancy or breastfeeding. Side Effects Like all medications, Korlym can cause side effects in some patients. The most common side effects of Korlym include: - Nausea - Vomiting - Weakness - Fatigue - Headache - Dizziness - Elevated liver enzymes - Low potassium levels - Diarrhea - Rash Additionally, some patients may experience more serious side effects, such as elevated blood sugar levels, menstrual irregularities, and adrenal insufficiency. Your healthcare provider will monitor you closely while you are taking Korlym to ensure that you are not experiencing any adverse effects. Interactions Korlym may interact with other medications that you are taking, so it is important to inform your healthcare provider about all of the medications, supplements, and vitamins that you are currently taking. Some medications that may interact with Korlym include antifungal medications, anticonvulsants, and hormonal contraceptives. Generic Options There is currently no generic version of Korlym available on the market. However, your healthcare provider may be able to prescribe a similar medication that is less expensive or more widely available. It is important to discuss all of your medication options with your healthcare provider to determine which one is right for you. In conclusion, Korlym is an effective medication that is used to manage the symptoms of severe endogenous Cushing's syndrome in adults. While it can cause some side effects in some patients, it is generally well-tolerated and is an important treatment option for people who have not responded well to other treatments. If you are considering taking Korlym, it is important to discuss all of your medication options with your healthcare provider to determine which one is right for you.