Isentress: A Comprehensive Guide to Understanding the Uses, Dosage, Demographic, Side Effects, Interactions, and Generic Options Isentress, also known by its generic name Raltegravir, is an antiretroviral medication that is used to treat Human Immunodeficiency Virus (HIV) infection. It was approved by the United States Food and Drug Administration (FDA) in 2007 and is available in the form of tablets and oral suspension. This article aims to provide a comprehensive guide to understanding the uses, dosage, demographic, side effects, interactions, and generic options of Isentress. Uses of Isentress Isentress is prescribed for the following purposes: 1. HIV treatment: Isentress is used in combination with other HIV medications to treat HIV infection in adults and children above the age of one. It belongs to a class of drugs called integrase inhibitors and works by blocking an enzyme in the virus that allows it to replicate. 2. HIV prevention: Isentress is also used in combination with other medications for HIV pre-exposure prophylaxis (PrEP) in adults who are at high risk of acquiring HIV infection through sexual or injectable drug use. Dosage of Isentress The dosage of Isentress is based on the patient's body weight and medical condition. The recommended dosage for adults and children weighing over 40 kg is 400 mg twice a day, while for children weighing between 20-40 kg, the dosage is 6 mg/kg twice a day, and for those weighing less than 20 kg, the dosage is 8 mg/kg twice a day. It can be taken with or without food. Demographic of Isentress Isentress is prescribed for individuals who have been diagnosed with HIV infection. It is generally safe for adults and children above the age of one. However, Isentress should be used with caution in patients with renal impairment and hepatic impairment. It is not recommended for use in pregnant women unless the benefits outweigh the risks. Side Effects of Isentress The following are some of the potential side effects of Isentress: 1. Headache 2. Dizziness 3. Insomnia 4. Nausea 5. Vomiting 6. Diarrhea 7. Rash 8. Abdominal pain 9. Muscle pain 10. Fatigue 11. Anemia 12. Elevated liver enzymes 13. Low white blood cell count Interactions of Isentress Isentress may interact with other medications and supplements. Some of the common interactions include: 1. Antacid drugs 2. Polyvalent cation-containing drugs 3. Rifampin 4. Phenytoin 5. Carbamazepine 6. St. John's wort Generic Options for Isentress Raltegravir, the generic version of Isentress, is also available in the market. The generic version is similar in effectiveness and safety to the brand name drug but is often cheaper. Conclusion Isentress is an effective medication for the treatment of HIV infection. It is essential to follow the dosage and instructions provided by the healthcare provider to prevent potential side effects. Isentress can interact with other medications, and it is important to inform the healthcare provider about all medications and supplements being taken. The generic version of Isentress is available and can be a more affordable option for patients who need HIV medication. As with all medications, it is important to consult with a healthcare provider before starting Isentress to ensure that it is safe and appropriate for an individual’s unique medical needs.