Gilotrif (afatinib) is a prescription medication used to treat certain types of non-small cell lung cancer (NSCLC) that has spread to other parts of the body. In this article, we’ll take a closer look at Gilotrif, including its uses, dosage, demographic, potential side effects, drug interactions, and availability of generic options. Uses of Gilotrif Gilotrif is classified as a kinase inhibitor, a type of medication that helps to block the actions of specific enzymes in cancer cells that cause them to multiply and spread. The drug is typically prescribed for patients who have been diagnosed with NSCLC that is positive for epidermal growth factor receptor (EGFR) mutations. EGFR mutations are genetic abnormalities that are present in approximately 10-15% of NSCLC cases. Gilotrif is only effective for treating NSCLC with these mutations, and it works by inhibiting the process by which certain growth factors bind to and activate EGFRs in cancer cells. Dosage of Gilotrif Gilotrif is available in tablet form and is typically taken once a day with water, and with or without food. The prescribed dose may vary depending on a variety of factors, such as the patient’s age, gender, weight, and overall health. It’s important for patients to follow their doctors’ instructions carefully, and not to take more or less Gilotrif than prescribed. Patients should also avoid crushing or chewing the tablets, as this could affect the way the medication is absorbed into the body. Demographic for Gilotrif According to the manufacturer, Gilotrif is approved for use in adults with NSCLC who have confirmed EGFR mutations. The drug has not been approved for use in children or teenagers, and its safety and efficacy have not been established in this population. Side Effects of Gilotrif Like all medications, Gilotrif can cause side effects in some patients. The most common side effects associated with the drug include: - Diarrhea - Rash or dry skin - Mouth sores - Nail changes - Loss of appetite - Nausea - Vomiting - Fatigue - Weakness - Eye irritation or sensitivity to light Patients who experience any of these side effects should contact their healthcare provider right away. In rare cases, Gilotrif can cause more serious side effects, such as severe diarrhea, skin reactions, or lung problems. Drug Interactions with Gilotrif Gilotrif has the potential to interact with other medications that a patient may be taking. Patients should inform their healthcare provider of all medications, supplements, and herbal remedies they are currently taking before starting Gilotrif. In particular, patients should avoid taking any other medications that can cause liver damage or interfere with the liver’s ability to metabolize Gilotrif. This includes certain antibiotics, antifungal medications, and antiviral medications, as well as certain over-the-counter pain relievers. Generic Options for Gilotrif As of 2021, there are currently no generic versions of Gilotrif available in the United States. The drug’s manufacturer has a patent on the medication that expires in 2021, and it is unclear if or when a generic version will be available. Conclusion Gilotrif is a prescription medication used to treat certain types of non-small cell lung cancer that has spread to other parts of the body. The drug works by blocking the actions of certain enzymes in cancer cells that cause them to grow and spread. Patients prescribed Gilotrif should follow their doctor’s instructions carefully, and be aware of potential side effects and drug interactions. As of now, there are no generic options for Gilotrif, but patients should work with their healthcare provider to explore other treatment options if needed.