. Folotyn (pralatrexate) is a chemotherapy drug that is used for the treatment of a specific type of cancer called peripheral T-cell lymphoma (PTCL), a rare and aggressive form of non-Hodgkin lymphoma. This drug is also used for patients with relapsed or refractory PTCL, or both. This article covers important information about Folotyn, including its uses, dosage, demographic, side effects, interactions, and generic options. Uses of Folotyn Folotyn is a type of chemotherapy drug that works by interfering with DNA synthesis and cell division, leading to the death of cancer cells. It is specifically designed to target cancer cells in patients with PTCL, a type of lymphoma that affects the T-cells (white blood cells) of the immune system. PTCL is a rare form of non-Hodgkin lymphoma that is often difficult to diagnose and treat. Folotyn is used in the treatment of PTCL, both relapsed or refractory, or both. The drug is also used as a second or third-line treatment for these patients if other initial treatments have not worked. Dosage of Folotyn The dosage of Folotyn is usually based on the patient's body surface area (BSA), which is calculated using height and weight measurements. The drug is usually administered intravenously or by injection, depending on the patient's condition. The recommended starting dose for Folotyn is 30 mg/m2 once a week for six weeks. After the initial six weeks of treatment, the patient will have a two-week break, followed by another six-week treatment cycle. If the patient's body tolerates the drug well, the dosage of Folotyn may be increased to 40 mg/m2 per week. Demographic of Folotyn Folotyn is used in the treatment of PTCL, particularly in adults aged 18 years or older. According to the National Cancer Institute, PTCL makes up only about 10-15 percent of all non-Hodgkin lymphomas, with an estimated 9,500 new cases per year in the United States. Folotyn is therefore targeted at this specific population. Side Effects of Folotyn Like most chemotherapy drugs, Folotyn can have several side effects that may vary from patient to patient. Among the most common side effects of this drug are fatigue, dizziness, nausea, vomiting, diarrhea, loss of appetite, anemia, and low white blood cell count. Other possible side effects include skin rashes, itching, mouth sores, and hair loss. In some cases, Folotyn may cause severe side effects that require immediate medical attention. These include allergic reactions, severe infections, kidney or liver problems, or lung problems. Patients should communicate any adverse reactions to their healthcare providers as soon as possible. Interactions of Folotyn Folotyn may interact with other medications or supplements, which may affect its efficacy or increase the risk of side effects. Patients should inform their healthcare provider about any medications they are taking, including prescription medications, over-the-counter drugs, vitamins, or supplements. Folotyn may interact with metformin, which is a medication used to treat diabetes, and folic acid supplements. Patients should inform their healthcare provider if they are taking these medications or supplements before starting treatment with Folotyn. Generic Options of Folotyn Currently, there is no generic version of Folotyn available on the market. However, there are other chemotherapy drugs used for the treatment of PTCL, such as romidepsin, belinostat, and pralatrexate. Conclusion Folotyn is a chemotherapy drug used for the treatment of peripheral T-cell lymphoma (PTCL), a rare and aggressive form of non-Hodgkin lymphoma. The drug interferes with DNA synthesis and cell division, leading to the death of cancer cells. Folotyn is used in the treatment of relapsed or refractory PTCL, or both, and its dosage is usually based on the patient's body surface area. Like most chemotherapy drugs, Folotyn can have several side effects, such as fatigue, dizziness, and nausea. Patients should communicate any adverse reactions to their healthcare providers. Folotyn may also interact with other medications or supplements, and patients should inform their healthcare providers if they are taking any other medications. There is currently no generic version of Folotyn available.