Duzallo: A Comprehensive Guide to Uses, Dosage, Demographics, Side Effects, Interactions, and Generic Options Duzallo is a medication that is used for the treatment of hyperuricemia in adult patients who have not responded adequately to a xanthine oxidase inhibitor alone. Hyperuricemia is a condition that occurs when there is an excessive amount of uric acid in the blood, and it can lead to a number of health complications including gout, kidney stones, and acute kidney injury. Duzallo combines lesinurad and allopurinol to lower the levels of uric acid in the body. In this article, we will provide a comprehensive guide to Duzallo by covering its uses, dosage, demographics, side effects, interactions, and generic options. Uses: Duzallo is indicated for the treatment of hyperuricemia in adult patients who have not achieved target serum uric acid levels with a xanthine oxidase inhibitor alone. Duzallo combines two drugs, lesinurad and allopurinol, to lower uric acid levels in the blood. Lesinurad works by blocking the reabsorption of uric acid in the kidneys, while allopurinol works by inhibiting the production of uric acid. Together, they can effectively lower the levels of uric acid in the body. Dosage: The recommended dose of Duzallo is one tablet (200 mg lesinurad/300 mg allopurinol) once daily. The tablet should be taken with food and water to reduce the risk of gastrointestinal side effects. The dosage should be adjusted for patients with moderate to severe renal impairment or hepatic impairment, and for patients taking certain medications that may interact with Duzallo. Demographics: Duzallo is approved for use in adult patients who have not achieved target serum uric acid levels with a xanthine oxidase inhibitor alone. It is not recommended for use in pediatric patients, pregnant or breastfeeding women, or patients with severe renal or hepatic impairment. The safety and efficacy of Duzallo have not been established in patients with a history of recurrent calcium oxalate stones or those with a baseline serum creatinine level greater than 2 mg/dL in obese patients. Side Effects: Duzallo may cause side effects, some of which could be serious. The most common adverse reactions reported in clinical trials were headache, influenza-like symptoms, and increased creatinine. Other side effects that have been reported include liver enzyme abnormalities, rash, and hypersensitivity reactions. Patients should be monitored for signs of hypersensitivity, and Duzallo should be discontinued immediately if a severe reaction occurs. Interactions: Duzallo may interact with certain medications, so patients should inform their healthcare provider of all the medications they are taking. Duzallo should not be used with azathioprine or mercaptopurine due to the risk of bone marrow suppression. Duzallo may also interact with drugs metabolized by the CYP3A4 or CYP2D6 pathways, such as rifampin, ketoconazole, and fluoxetine. Patients should be monitored for potential drug interactions and dosage adjustments may be necessary. Generic options: Duzallo is a combination drug that contains two active ingredients, lesinurad and allopurinol. While there are no generics currently available for Duzallo, both lesinurad and allopurinol are available in generic form. Patients may be able to save money by using the individual generic drugs instead of the combination drug. However, patients should consult with their healthcare provider before making any changes to their medication regimen. In conclusion, Duzallo is a medication used for the treatment of hyperuricemia in adult patients who have not responded adequately to a xanthine oxidase inhibitor alone. It combines lesinurad and allopurinol to lower uric acid levels in the blood. Patients should take the medication as prescribed and be aware of potential side effects and drug interactions. While there are no generics currently available for Duzallo, both lesinurad and allopurinol are available in generic form. Patients should inform their healthcare provider of all the medications they are taking and consult with them before making any changes to their medication regimen.