Duexis: An Overview of Uses, Dosage, Demographic, Side Effects, Interactions, and Generic Options Duexis is a medication that is commonly used to treat osteoarthritis and rheumatoid arthritis. This drug is a combination of two active ingredients, ibuprofen and famotidine. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that reduces inflammation and pain, while famotidine is an H2 blocker that helps reduce the risk of gastrointestinal ulcers. Uses According to the manufacturers, Duexis is intended for the short-term treatment of the signs and symptoms of osteoarthritis and rheumatoid arthritis in patients who require therapy with an NSAID and who are at risk of developing gastric and/or duodenal ulcers and their complications. Dosage The recommended dosage for Duexis is one tablet taken two times daily with food. The drug should be used at the lowest effective dose for the shortest amount of time. The total dose of ibuprofen in a 24-hour period should not exceed 1,200 mg. Demographic Duexis is approved for use in adults aged 18 years and older. Side Effects Some possible side effects of Duexis include abdominal pain, constipation, diarrhea, dyspepsia, headache, nausea, and vomiting. Serious but rare side effects that may occur include allergic reactions, anemia, bleeding, liver damage, and kidney problems. Patients should discuss all potential side effects with their healthcare provider before starting Duexis. Interactions Patients should inform their healthcare provider of all medications they are taking before starting Duexis. Some medications may interact with Duexis, including anticoagulants, aspirin, corticosteroids, diuretics, lithium, methotrexate, and others. Generic options Ibuprofen and famotidine are both available as generic medications, which can make them a more cost-effective alternative to Duexis. However, it is important to note that generic medications may not be identical to the brand-name version and may have slightly different dosages or inactive ingredients. Conclusion Duexis is a combination medication used to treat inflammation and pain associated with osteoarthritis and rheumatoid arthritis. It is important to note that Duexis should only be used for short periods of time and at the lowest effective dose possible. Patients should also consult with their healthcare provider about all potential side effects and drug interactions before starting Duexis. Lastly, generic alternatives to Duexis are available and may be a more cost-effective option for patients.