Clozaril (clozapine) - An Atypical Antipsychotic Medication Clozaril, or clozapine, is a medication prescribed to treat schizophrenia. It is an atypical antipsychotic medication that is used when other treatment options have failed. Clozaril works by blocking certain receptors in the brain that are responsible for psychotic symptoms. Uses Clozaril is used to treat schizophrenia in people who have not responded to other medications. It is also used to reduce the risk of suicidal behavior in people with schizophrenia or schizoaffective disorder. Dosage Clozaril is available as tablets of 25 mg, 50 mg, 100 mg and 200 mg strengths. The dosage is based on the individual's response to treatment. The starting dose is usually 12.5 mg once or twice daily, with gradual increases up to a maximum of 900 mg per day. The medication is usually taken once or twice a day with or without food. Demographic Clozaril is approved for use in adults only. It is prescribed to people with schizophrenia or schizoaffective disorder who have not responded to other antipsychotic medications. Clozaril is not recommended for use in children. Side Effects Common side effects of Clozaril include dizziness, drowsiness, dry mouth, headache, increased sweating, weight gain, and constipation. Clozaril can also cause serious side effects such as seizures, changes in blood pressure and heart rate, low white blood cell count, and a rare condition called agranulocytosis, which can be life-threatening. Regular monitoring of blood tests is necessary to monitor for low white blood cell count or other potential side effects. Interactions Clozaril can interact with other medications, including other antipsychotic medications, drugs that affect the heart, antibiotics, and certain medications for depression or anxiety. It is important to inform your doctor of all medications you are taking before starting Clozaril to prevent any harmful interactions. Generic Options Clozaril is only available as a brand name medication, but generic options are available for other atypical antipsychotic medications used to treat schizophrenia, such as aripiprazole and risperidone. Conclusion Clozaril is a medication used to treat schizophrenia in people who have not responded to other treatment options. The dosage is determined based on the individual's response to treatment. While the medication is generally well-tolerated, it can cause serious side effects and can interact with other medications. Regular monitoring and consultations with a healthcare provider are necessary when taking Clozaril.