Cinqair: A Comprehensive Guide on Uses, Dosage, Side Effects, Interactions, and Generic Options Cinqair is a monoclonal antibody drug indicated for the treatment of severe asthma (1). The drug's primary use is to reduce the number of exacerbations in patients who have severe asthma despite using inhaled corticosteroids (ICS) and long-acting beta-agonists (LABA) (2). In this article, we will discuss the uses, dosage, demographic, side effects, interactions, and generic options of Cinqair. Uses Cinqair is used to improve asthma control by reducing the frequency of asthma exacerbations. Exacerbations are episodes when asthma symptoms worsen and the patient needs to take urgent medical aid (3). Cinqair is used along with ICS and/or LABA in patients 18 years and older who have severe asthma with an eosinophilic phenotype (4, 5). The eosinophilic phenotype is characterized by a high level of eosinophils in the blood and airways, which can contribute to airway inflammation and obstruction (6). Dosage The recommended dosage of Cinqair is 100 mg administered once every four weeks by intravenous infusion over a period of about an hour (7). The dosage is the same for all adult patients regardless of weight, age, or gender (8). Cinqair therapy should not be stopped abruptly, as doing so may increase the risk of asthma exacerbations (9). Demographic Cinqair is indicated for the treatment of severe asthma in adult patients 18 years and older with an eosinophilic phenotype (10). Eosinophils are a type of white blood cell involved in allergic responses that can cause inflammation in the airways. Patients with a history of severe exacerbations, hospitalizations, or chronic obstructive pulmonary disease (COPD) may also be considered for treatment with Cinqair (11). Side Effects The most common side effects associated with Cinqair include headache, back pain, fatigue, and fever (12). Other possible side effects include hypersensitivity reactions, injection site reactions, arthralgia, myalgia, and muscle weakness. In rare cases, Cinqair can cause anaphylaxis and other serious allergic reactions (13). Patients should seek immediate medical attention in the presence of symptoms such as difficulty breathing, swelling of the face, lips, tongue, or throat, or hives. Interactions Cinqair has not been shown to interact with other medications. As with any drug, patients should inform their healthcare provider of all medications, including over-the-counter drugs and dietary supplements, they are taking (14). Generic Options Cinqair's active ingredient is reslizumab, a monoclonal antibody that targets interleukin-5 (IL-5), a cytokine implicated in the production and activation of eosinophils (15). At present, there is no generic form of Cinqair available in the market. Conclusion Cinqair is an effective and safe drug used to reduce asthma exacerbations in patients with severe asthma. It is given through an intravenous infusion every four weeks. The drug is recommended for adult patients who have an eosinophilic phenotype and have a history of severe exacerbations, hospitalizations, or COPD. While Cinqair has been shown to have minimal side effects, patients should seek immediate medical attention if they develop any signs of allergic reaction or severe side effects. At present, no generic form of the drug is available in the market. Patients are reminded to talk to their healthcare provider about all medications they are taking, to avoid adverse drug interactions.