Byetta: Uses, Dosage, Demographics, Side Effects, Interactions, and Generic Options Introduction Byetta (generic name: exenatide) is a medication used in the treatment of type 2 diabetes mellitus. Byetta is classified as a glucagon-like peptide-1 (GLP-1) receptor agonist, which means it mimics the action of the natural hormone GLP-1 in the body. Byetta is administered via subcutaneous injection and is usually taken with meals. This article will provide an in-depth look at the use, dosage, demographics, side effects, interactions, and generic options for Byetta. Uses Byetta is used to treat type 2 diabetes mellitus. Byetta works by increasing the production of insulin, decreasing the production of glucagon, and slowing the rate at which the stomach empties food into the small intestine. Byetta is used in combination with diet and exercise to control blood sugar levels in people with type 2 diabetes. Byetta has also been studied for its potential use in the treatment of obesity and polycystic ovary syndrome (PCOS). However, these uses have not been approved by the U.S. Food and Drug Administration (FDA) at this time. Dosage Byetta is available in two formulations: Byetta Pen and Byetta Syringe. The Byetta Pen delivers doses of 5 mcg or 10 mcg per injection, while the Byetta Syringe delivers doses of 5 mcg, 10 mcg, or 20 mcg per injection. The recommended starting dose of Byetta is 5 mcg, taken twice a day, 60 minutes before the morning and evening meals. After one month of treatment, the dose is increased to 10 mcg, taken twice a day, 60 minutes before the morning and evening meals. Demographics Byetta is approved for use in adults with type 2 diabetes who are not achieving adequate glycemic control with diet and exercise alone. Byetta should not be used to treat type 1 diabetes or diabetic ketoacidosis. Byetta has not been studied in pregnant women or children under the age of 18. Byetta may be a good choice for people who have difficulty controlling their blood sugar levels with oral medications alone or for people who want to avoid insulin therapy. Byetta is not recommended for people with severe kidney or liver disease or for people who have had a history of pancreatitis. Side Effects Like all medications, Byetta can cause side effects. The most common side effects of Byetta include nausea, vomiting, diarrhea, headache, dizziness, and constipation. These side effects usually go away on their own after a few days or weeks of treatment. Serious side effects of Byetta include low blood sugar (hypoglycemia), pancreatitis, and kidney failure. Symptoms of hypoglycemia include sweating, shaking, confusion, and rapid heartbeat. Symptoms of pancreatitis include severe abdominal pain, nausea, and vomiting. Symptoms of kidney failure include swelling, fatigue, and high blood pressure. If you experience any of these serious side effects, contact your healthcare provider immediately. Interactions Byetta may interact with other medications or supplements you are taking. Byetta can slow down the rate at which food leaves the stomach, which can affect the absorption of other medications. Byetta may also affect the absorption of certain vitamins and minerals, such as calcium and vitamin B12. It is important to tell your healthcare provider about all medications and supplements you are taking before starting treatment with Byetta. This includes prescription medications, over-the-counter medications, vitamins, and herbal supplements. Generic Options Byetta is currently available in a generic form called exenatide, which is made by several different pharmaceutical companies. The cost of generic exenatide is typically less than the cost of branded Byetta. However, generic exenatide may not be covered by all insurance plans, so it is important to check with your insurance provider before switching to a generic form of the medication. Conclusion Byetta is a medication used in the treatment of type 2 diabetes mellitus. Byetta works by increasing the production of insulin, decreasing the production of glucagon, and slowing the rate at which the stomach empties food into the small intestine. Byetta is administered via subcutaneous injection and is usually taken with meals. Byetta is not recommended for people with severe kidney or liver disease or for people who have had a history of pancreatitis. Byetta has a number of potential side effects, including low blood sugar, pancreatitis, and kidney failure. Byetta may interact with other medications or supplements, so it is important to tell your healthcare provider about all medications and supplements you are taking before starting treatment. Byetta is available in a generic form called exenatide, which may be less expensive than the branded version.