Bosulif: A Comprehensive Guide Bosulif, also known as bosutinib, is a prescription medication used to treat chronic myeloid leukemia (CML). It belongs to the class of medications known as tyrosine kinase inhibitors, which work by blocking the action of certain enzymes that cause cancer cells to grow. In this article, we will explore the uses, dosage, demographics, side effects, interactions, and generic options for Bosulif. Uses Bosulif is used in the treatment of chronic phase, accelerated phase, or blast phase Philadelphia chromosome positive chronic myeloid leukemia (Ph+ CML). It is typically prescribed for patients who have not responded to or cannot tolerate other CML treatments. Dosage Bosulif is available in 100 mg and 500 mg tablets. The recommended dosage is 400 mg daily, taken orally with food. Patients should not crush or break the tablet, and should swallow it whole with a glass of water. Patients with mild or moderate liver impairment may require a reduced dosage, while those with severe liver impairment should not take Bosulif. Demographics Bosulif is approved for use in adults aged 18 years and older. It may not be suitable for patients with: - Hypersensitivity to Bosulif or its components - Severe liver impairment - History of pancreatitis - History of bleeding disorders It is important to talk to your healthcare provider about any medical conditions or medications you are taking before starting Bosulif. Side Effects Like all medications, Bosulif can cause side effects. Common side effects include: - Diarrhea - Nausea and vomiting - Abdominal pain - Fatigue - Rash - Headache - Musculoskeletal pain - Fever - Cough Some patients may also experience more serious side effects, such as: - Low blood counts (anemia, neutropenia, thrombocytopenia) - Liver toxicity - Pancreatitis - Bleeding disorders - Anaphylaxis Patients should contact their healthcare provider immediately if they experience any of these symptoms. Interactions Bosulif should not be taken with certain medications, including: - Strong CYP3A4 inhibitors (i.e. itraconazole, ketoconazole, clarithromycin) - Strong CYP3A4 inducers (i.e. rifampin, carbamazepine, phenytoin, St. John's wort) - Drugs that prolong the QT interval (i.e. amiodarone, quinidine, chlorpromazine) Patients should inform their healthcare provider of all medications and supplements they are taking before starting Bosulif. Generic options There are currently no generic versions of Bosulif available in the United States. However, patients may be able to access less expensive versions of the medication through alternative sourcing options, such as international online pharmacies or discount drug programs. Conclusion Bosulif is a prescription medication used to treat chronic myeloid leukemia. It is important for patients to follow the recommended dosage and inform their healthcare provider of any medical conditions or medications they are taking. While Bosulif can cause side effects, most are mild and can be managed. Patients should contact their healthcare provider immediately if they experience any serious side effects. For patients looking for lower-cost options, alternative sourcing options may be available.