Aloxi (palonosetron) - Uses, Dosage, Demographic, Side Effects, Interactions, and Generic Options Aloxi is a prescription medication used to prevent nausea and vomiting caused by chemotherapy. The drug has been approved by the FDA since 2008 and is only available with a healthcare provider's prescription. Here's what you need to know about Aloxi, including its uses, dosage, demographic, side effects, interactions, and generic options. Uses of Aloxi Aloxi is used to prevent acute and delayed nausea and vomiting in adults undergoing chemotherapy that is highly likely to cause nausea and vomiting. Dosage of Aloxi The recommended dosage of Aloxi is 0.25 mg IV, administered over 30 seconds, approximately 30 minutes before the start of chemotherapy. The medication is available in a single-use vial and is for intravenous use only. Demographic for Aloxi Aloxi is indicated for use in adults who are undergoing chemotherapy that is highly likely to cause nausea and vomiting. The drug's efficacy in pediatric patients has not been established, and the safety of the medication in pregnant women and breastfeeding mothers is not known. Side Effects of Aloxi As with all medications, Aloxi may cause side effects. Some common side effects of Aloxi include headache, constipation, and diarrhea. Other possible side effects may include: - Fatigue - Dizziness - Dyspepsia (indigestion) - Abdominal pain - Flatulence - Hyperhidrosis (excessive sweating) - Anemia - Leukopenia (low white blood cell count) - Increased liver enzyme levels In rare cases, Aloxi may cause an allergic reaction. If you experience any symptoms of an allergic reaction, such as hives, difficulty breathing, or swelling of the face, lips, tongue, or throat, seek immediate medical attention. Interactions of Aloxi Aloxi may interact with other medications, including: - CYP3A4 inhibitors (such as clarithromycin, ketoconazole, and ritonavir) - CYP2D6 inhibitors (such as fluoxetine and paroxetine) - Inducers of CYP3A4 (such as rifampin and St. John's Wort) Before taking Aloxi, inform your healthcare provider of all medications, vitamins, and supplements you are taking to avoid potential interactions. Generic Options for Aloxi Aloxi is a brand-name medication and does not have a generic version available. However, the active ingredient in Aloxi, palonosetron, is available in generic form in other medications used to treat nausea and vomiting, such as Akynzeo and Saphris. Conclusion Aloxi is a prescription medication used to prevent acute and delayed nausea and vomiting caused by chemotherapy in adults. The drug is administered intravenously and is typically given 30 minutes before the start of chemotherapy. While Aloxi may cause side effects, the medication is generally well-tolerated. Patients should inform their healthcare providers of all medications they are taking to avoid potential interactions. While Aloxi is not available in generic form, some other medications containing the same active ingredient are available in generic forms.